Repair enzyme action, determinants

Most contemporary mechanistic models are based on the hypothesis that the action of various modes of DNA repair on lesions in DNA is the critical determinant of mutagenesis and survival. For our purposes, all modes of DNA repair can be regarded operationally as being either error-free (EFR) or error-prone (EPR) the relationship of these operational concepts to DNA replication or the enzyme complexes involved need not concern us here. Thus, we can write the following general mechanistic equations for the hit functions introduced in equations (4)-(6) ... 

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