Renierone from Reniera

Several isoquinolinequinones are natural products. From a bright-blue marine sponge of Reniera sp., renierone (260) was isolated as the major antimicrobial antimetabolite (79TL4163). Later, related quinones were isolated... 

A sponge belonging to the genus Reniera furnished a series of antimicrobial isoquinolines and an isoindole derivative (197), renierone (319), mimosamycin (320), N-formyl-l,2-dihydrorenierone (321), 0-de-methylrenierone (322), 1,6-dimethyl-7-methoxy-5,8-dihydroisoquino-line-5,8-dione (323), 2,5-dimethyl-6-methoxy-4,7-dihydroisoindole-4,7-dione (324), and renieramycins A-D (325-328). Mimosamycin (320) was originally isolated from Streptomyces lavendulae. Compounds 319 and 321, both inhibited cell division in the fertilized sea urchin egg assay. 

Kubo, A., Nakahara, S., Inaba, K., and Kitahara, Y. (1986) Synthesis of renierone and derivatives, antimicrobial metabolites from a marine sponge, Reniera sp. Chem. Pharm. Bull., 34, 4056—4068. 

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