Renal insufficiency gabapentin

Renal insufficiency gabapentin is excreted via the kidneys thus dose should be adjusted based on creatinine clearance. 

A 30-year-old woman with renal insufficiency on hemodialysis three times a week suffered no significant toxicity after ingesting 600 mg tds of gabapentin for 3 weeks, a large dose in view of her impaired kidney function (43). The blood gabapentin concentration was 496 pmol/1. 

Sensory systems Hearing loss was attributed to high concentrations of gabapentin in a patient with renal insufficiency [117 ]. 

Musculoskeletal Gabapentin can rarely cause a myopathy and rhabdomyolysis. Myoglobinuria, causing acute renal insufficiency, has been described in a patient with painful diabetic neuropathy [122 ]. 

Susceptibility factors Renal disease Unrecognized gabapentin toxicity, mainly characterized by a significant deterioration in consciousness, occurred in a patient with acute renal impairment [123 ]. During episodes of acute renal insufficiency the dose of gabapentin should be reduced. 

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