Renal failure intravenous immunoglobulin

Gras V, Andrejak M, Decocq G. Acute renal failure associated with intravenous immunoglobulins. Pharmacoepidemiol Drug Saf 1999 8(Suppl l) S73-8. 

Pasatiempo AM, Kroser JA, Rudnick M, Hoffman BI. Acute renal failure after intravenous immunoglobulin therapy. J Rheumatol 1994 21(2) 347-9. 

Tsinahs D, Dickenmann M, Brunner F, Gurke L, Mihatsch M, Nickeleit V. Acute renal failure in a renal allograft recipient treated with intravenous immunoglobulin. Am J Kidney Dis 2002 40(3) 667-70. 

Itkin YM and Trujillo TC. Intravenous immunoglobulin-associated acute renal failure case series and literature review. Phama-cotherapy 2005 25 886-892... 

Tan E, Flajinazarian M, Bay W, NefFJ, Mendell JR Acute renal failure resulting from intravenous immunoglobulin therapy. Arch Neurol 1993,50 137-139... 

Maltose is used in oral and parenteral pharmaceutical formulations and is generally regarded as an essentially nontoxic and nonirritant material. However, there has been a single report of a liver transplantation patient with renal failure who developed hyponatremia following intravenous infusion of normal immunoglobulin in 10% maltose. The effect, which recurred on each of four successive infusions, resembled that of hyperglycemia and was thought to be due to accumulation of maltose and other osmotically active metabolites in the extracellular fluid. ... 

Urinary tract Acute renal failure, usually oliguric and transient, occurs rarely after treatment with intravenous immunoglobulin the incidence is less than 1%, but it is more frequent in patients with other susceptibility factors for renal failure [39 , 40 ,43, 57 ]. This reversible reaction occurs mostly (90%) with sucrose-containing products, leading to osmotic injury and tubular damage [30, 41. ... 

In this case, there were multiple susceptibility factors the patient s age, the sucrose-containing immunoglobulin product, the first administration, and the high infusion rate. Another case of acute renal failure after administration of intravenous immunoglobulin to a 87-year-old woman has been described [58" ]. Proteinuria can also occur [40 ]. 

Deep venous thrombosis occurred in a bed-bound patient, and acute renal failure in a patient with diabetic nephropathy after intravenous immunoglobulin [40 ]. 

Graumann A, Zawada ET Jr. Case report acute renal failure after administering intravenous immunoglobulin. Postgrad Med 2010 122(2) 142-7. 

---