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Renal disease niacin

Contraindications Thiamine patients with renal dysfunction Riboflavin patients with renal dysfunction Niacin or nicotinic acid hypersensitivity to niacin or tartrazine active peptic ulcer, severe hypotension, hepatic dysfunction, arterial hemorrhaging Caution diabetes mellitus, gallbladder disease, gout, history of jaundice or Uver disease. Pyridoxine IV therapy in cardiac patients Caution megadosage in pregnancy... [Pg.170]

A number of genetic diseases that result in defects of tryptophan metabolism are associated with the development of pellagra despite an apparently adequate intake of both tryptophan and niacin. Hartnup disease is a rare genetic condition in which there is a defect of the membrane transport mechanism for tryptophan, resulting in large losses due to intestinal malabsorption and failure of the renal resorption mechanism. In carcinoid syndrome there is metastasis of a primary liver tumor of enterochromaffin cells which synthesize 5-hydroxy-tryptamine. Overproduction of 5-hydroxytryptamine may account for as much as 60% of the body s tryptophan metabolism, causing pellagra because of the diversion away from NAD synthesis. [Pg.490]

Hartnup disease is a rare genetic condition in which there is a defect of the membrane transport mechanism for tryptophan and other large neutral amino acids. The result is that the intestinal absorption of free tryptophan is impaired, although dipeptide absorption is normal. There is a considerable urinary loss of tryptophan (and other amino acids) as a result of the failure of the normal reabsorption mechanism in the renal tubules - renal aminoaciduria. In addition to neurological signs that can be attributed to a deficit of tryptophan for the synthesis of serotonin in the central nervous system, the patients show clinical signs of pellagra, which respond to the administration of niacin. [Pg.224]

Niacin (adult RDA = 13 mg = 13 niacin equiv.) 50-250 mg Hartnup disease Intestinal and renal transport of tryptophan (high protein diet needed in addition to niacin to relieve symptoms)... [Pg.902]

Cho, K.H., Kim, H.J., Kamanna, V.S., and Vaziri, N.D., 2010. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Biochimica et Biophysica Acta. 1800 6 15. [Pg.684]


See other pages where Renal disease niacin is mentioned: [Pg.94]    [Pg.446]    [Pg.278]    [Pg.258]    [Pg.190]    [Pg.224]    [Pg.938]    [Pg.219]    [Pg.613]    [Pg.84]   
See also in sourсe #XX -- [ Pg.643 , Pg.644 , Pg.648 ]




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