Muscle rigidity remifentanil

Remifentanil has been studied in neonates undergoing elective endotracheal intubation [178 ]. They were randomized to remifentanil 3 micrograms/kg-I-isotonic sahne ( = 15) or fentanyl 2 micrograms/kg - - suxamethonium 2 mg/kg. There was chest wall rigidity in two of the infants who received remifentanil. Muscle rigidity remains a concern in doses of 3 micrograms/kg in this age group. 

General anesthesia - Remifentanil is not recommended as the sole agent in general anesthesia because loss of consciousness cannot be assured and because of a high incidence of apnea, muscle rigidity, and tachycardia. Remifentanil is synergistic with other anesthetics and doses of thiopental, propofol, isoflurane, and midazolam have been... 

Remifentanil is liable to cause respiratory depression in children (33,34), as well as muscle rigidity, hypotension, and bradycardia, without increasing the incidence of gastrointestinal symptoms (35). 

Side effects remifentanil may cause adverse effects characteristic of p opioids, such as respiratory depression, bradycardia, hypotension, primitus, and skeletal muscle rigidity. 

Bolus remifentanil can be associated with thoracic muscle rigidity and consequent difficulty in mask or pressure-controlled ventilation [166 ]. 

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