Relationship Between Clearance, VDss and Plasma Protein Binding

3 Prediction of Human Volume of Distribution from In Silico Methods 

Relationship Between Clearance, VDss and Plasma Protein Binding 

From this model it is clear that, for example, highly bound dmgs with high CLim can exhibit low clearance. A common medicinal chemistry strategy to increase ti/2 is 

Finally, we note that plasma protein binding is generally determined on a retrospective or interpretation basis, and it is seldom determined routinely, as 

1 Benet, L.Z. and Hoener, B. (2002) Changes in plasma protein binding have little clinical relevance. Clinked Pharmacology and Therapeutics, 71, 115-121. 

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