Rejection mask

Fig. 10.10 Rejection mask used in Visual Empirical Region of Influence (VERI). The shape of the mask is mathematically derived from the visual cognitive factors (a) geometrical scaling relationships used in the derivation of the shape (b) final mask which defines the exclusion region, that is, objects that do not belong to the group (Osbourn and Martinez, 1995)...

Anyway, due to the limited precision of the EDP - intensity measurement, especially for the (100) reflection, which is too close to the central beam - this argument is not very strong and cannot reject the 1/3 substitution at all. To confirm the hypotheses of the proposed 2/3 substitution HREM observation in [001] and [021] zones were performed in parallel with multislice calculations, based on the 2/3 substitution. These projections are used because the fourfold modulation due to the Mo atoms is well expressed in them. The observed images are enhanced by a Fourier filter with Bragg mask to eliminate the noise frequencies. 

FK506 (tacrolimus), a natural product of Streptomyces tukubaensis, is a 23-membered macrolide antibiotic that contains a unique hemiketal-masked, a,P-diketo amide moiety (Fig. 1) [1]. It has a mode of action and toxicity profile similar to those of cyclosporin A (CsA), an immunosuppressive cyclic undecapeptide produced by Tolypocladium inflatum (Fig. 1), which has been used clinically for two decades to prevent rejection on transplantation of organs, such as kidney, heart, liver, and bone marrow. The use of CsA has led to a remarkable increase of survival of all organ allografts and has fueled a dramatic increase in the number of kidney, liver, cardiac, and bone marrow transplants [2]. Thus, CsA has revolutionized transplantation surgery, both in terms of efficiency and quality of life of the patient. FK506 is said to be a more potent immunosuppressant than CsA and was approved for the treatment and prevention of kidney transplant rejection. 

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