Rejection and Lung Transplantation

Marcel Dekker, Inc. 270 Madison Avenue. New York, New York 10016 

The CC chemokines have the first two-cysteine residues adjacent to each other (Cysteine-Cysteine). This subfamily usually does not act on resting neutrophils and is predominantly known as potent mononuclear cell chemoattractants (i.e., mononuclear phagocytes, lymphocytes, NK cells, basophils, and eosinophils) with variable selectivity. Similar to the CXC chemokines, the NH2-terminal amino acids preceding the CC residues determine their biologic activity and leu- 

There are 50 known chemokines and 20 chemokine receptors. Many have multiple traditional names, leading to confusion. This necessitated the need for a systematic nomenclature for chemokine ligands and chemokine receptors (27). The chemokine ligands are defined as CXC, CC, XC, and CX3C followed by L (ligand) and a number. The chemokine receptors are defined by the same structure-related acronyms followed by R (receptor) and a number (27) [see Chap. 1 (27)]. 

---