Regulation and Toxic Metabolites

Whereas the following discussion is directed primarily to the role of metabolites, environmental factors may also be important. Some examples including the role of oxygen concentration have already been given as illustration. 

Classic studies were devoted to the regulation of the enzymes for conversion of catechol and 3,4-dihydroxybenzoate (protocatechuate) to 3-ketoadipate by Pseudomonas putida (Ornston 1966), 

The induction of the monooxygenases for the degradation of trichloroethene by aromatic substrates and vice versa is discussed in Chapter 8, Part 1. 

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