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Regulation and Polymorphism

The induction of P450 1A1 has been studied extensively and is discussed elsewhere in this book . Briefly, the Ah receptor resides in the cytosol and, when activated by binding of an appropriate agonist, loses the accessory protein Hsp90 and dimerizes with the ARNT protein, moving to the nucleus and interacting with an XRE element [Pg.397]

Argikar U. Effects of age, induction, regulation and polymorphisms on the metabolism of antiepileptic drugs. In PhD. thesis. Minneapolis University of Minnesota, 2006. [Pg.123]

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Polymorphism and

Polymorphism and polymorphs

Regulation and Polymorphisms in Phase II Genes

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