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Regiocontrol in Epoxide-Opening Reactions

SCHEME 4.6 Regiocontrol through rational substrate design. [Pg.167]

Nicolaou engaged in an effort to reverse the regioselec-tivity of these reactions in the context of synthesizing the ladder toxins. This study was based on the hypothesis that [Pg.167]

SCHEME 4.7 iiwrfo-cyclization through reagent control. [Pg.168]

SCHEME 4.8 Cascade cyclization through epoxonium ion intermediates. [Pg.168]

The potential for interconverting hydroxy oxepanes and hydroxyalkyl tetrahydropyrans via epoxonium ion [Pg.168]


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Epoxide openings

Epoxide reaction

Epoxides reactions

Reactions epoxidation

Regiocontrol

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