Reductive Reactions Dehalogenation Including Dehalorespiration

Cytochrome P450 reduction of polyhalogenated alkanes has been demonstrated. For example, cells of Pseudomonas putida G786 containing cytochrome genes on the CAM plasmid were 

Selective reductive debromination of polyhalogenated methanes (Castro et al. 1985 Li and Wackett 1993). 

Under anaerobic conditions, various reactions can occur, and the following are illustrative (a) trichlorofluoromethane - carbon monoxide (b) hexachloroethane tetrachlo-roethene (c) l,l,l-trichloro-2,2,2-trifluoroethane l,l-dichloro-2,2-difluoroethene (Hur et al. 1994). 

The membrane-bonnd dehalogenase from Dehalobacter restrictus contained (per mole of subunit) 1 mol of cobalamin, 0.6 mol cobalt, 7 mol iron, and 6 mol acid-labile sulfur. 

It carried out dechlorination of tetra- and trichloroethene to di-l,2-dichloroethene, and had a substrate spectrum that included tetrachloromethane, hexachloroethane, and 1,1,1-trichloro-2,2,2-triflnorarethane althongh the products from these were not apparently identified (Maillard et al. 2003). 

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