Redox systems, P450 monooxygenases

Regio- and stereospecific monohydroxylations of elaborated molecules have been achieved with monooxygenases that are in most cases membrane-bound cytochrome P450 enzymes. Because these are coupled with a complex redox system for electron transport from NADPH, the reactions are preferably carried out with whole cells [52], The same is true for enantioselective enzymatic epoxida-tions. An impressive example documented in eq. (6) is the preparation of 18 in 78 % yield and high ee [53]. 

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