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Redox Physiology and the Role of AOS as Mediators in HPV

Marcel Dekker, Inc. 270 Madison Avenue. New York. New York 10016 [Pg.533]

Electrons flow down the ETC driven by a difference in the redox potential between--0.4 in [Pg.534]

The redox hypothesis of HPV proposes that there is a tonic, basal, normoxic production of AOS in the PASMCs. These AOS are most likely derived from their mitochondria, although contributions from other sources, such as plasmalemmal NADPH oxidase, cannot be excluded. This normoxic generation of AOS establishes [Pg.534]


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