Recurring Structures Devoid of Target Family Correlations

Recurring Structures Devoid of Target Family Correlations [Pg.22]

Since the spatial extent of the common underlying 1,2-di-phenyl substituted heterocycle by far exceeds that of a generic scaffold, and the nature of the underlying [Pg.23]

Loxapine (Lederle) neuroleptic D2-antagonist H1-antagonist M-antagonist [Pg.24]

Mianserin (Organon) antidepressant NA-uptake inhibitor H1 -antagonist a1-, a2-antagonist 5HT2A, 2B, 2C, 6, 7 antagonist [Pg.25]

Imipramine (Ciba-Geigy) antidepressant NA-, 5HT-uptake inhibitor al-antagonist M-antagonist 5HT2A, 2D, 6, antagonist CYP2D6 substrate [Pg.25]

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