Record linkage data

Stergachis A. Record linkage studies for post-marketing surveillance data quahty and vahdity considerations. Drugintell Clin Pharm 1988 22 157. 

Occasionally, neuropathies have been documented (6). The fear that cimetidine or ranitidine might increase the incidence of motor neuron disease was raised in the light of case-control work, but seems to have been allayed by data from the Oxford Record Linkage Study published in 1993 (7). 

G. Wagner and H. B. Newcombe, Record linkage, its methodology and application in medical data processing, Meth. Inform. Med. 9, 121-138 (1970). 

Fig. 10.19. IDR-HSQC-TOCSY spectrum of the complex marine polyether toxin brevetoxin-2 (7). The data were recorded overnight using a 500 pg sample of the toxin (MW = 895) dissolved in 30 pi of d6-benzene. The data were recorded at 600 MHz using an instrument equipped with a Nalorac 1.7 mm SMIDG probe. Direct responses are inverted and identified by red contours relayed responses are plotted in black. The IDR-HSQC-TOCSY data shown allows large contiguous protonated segments of the brevetoxin-2 structure to be assembled, with ether linkages established from either long-range connectivities in the HMBC spectrum and/or a homonuclear ROESY spectrum.

The conceptual model uses the Source -Pathway - Receptor Paradigm. The paradigm requires that each of the parameters within the model are documented, estimated, measured or recorded. The model identifies the source of any contamination identifies who or what is affected (the receptor) and identifies how the source may reach the receptor (pathway). The collection of field data, observations and estimates confirms whether a linkage exists between the source and receptor. 

The overall risk estimation should cover all the pollutant linkages identified, broken into site zones as appropriate. Details should be provided of source concentrations, with estimated confidence limits, the receptor characteristics and confirmation of the viability of the pollutant pathway. If generic guideline values are used, then their applicability should be supported. Clearly, full details need to be recorded of any models and data used to generate site-specific values for unacceptable risk, together with a commentary on assumptions that have been made in their application. 

Reference has already been made to the range of applications of DTA and DSC. This section is concerned with a closer look at calorimetric measurements which link thermal power to heat capacity, dAq/dt = (Cg — and its integral, dAq/dt)dt, to energy or enthalpy. These linkages together with temperature form the basis of quantitative DSC. Computer systems for the control of equipment, data capture and subsequent analysis have combined to give increased versatility and results of far greater precision than was possible previously with chart recorders. 

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