Receptors for AGE

Schmidt, A.M. and Stern, D.M. (2001) Receptor for AGE (RAGE) is a gene within the major histocompatibility class III region implications for host response mechanisms in homeostasis and chronic disease. Front. Biosci. 6, D1151-D1160. 

Also, interaction of AGEs with their receptors is thought to generate oxidative stress. Cellular interactions of AGEs are mediated by specific cellular binding proteins, receptors for AGE (RAGE). AGE-albumin or AGEs isolated from plasma of... 

Matsunaga N, Anan I, Forsgren S, Nagai R, Rosenberg R Horiuchi S, Ando Y, Suhr OB (2002) Advanced glycation end products (AGE) and the receptor for AGE are present in gastrointestinal tract of familial amyloidotic polyneuropathy patients but do not induce NF-kappaB activation. Acta Neuropathol (Berl)... 

IGFs, lipoproteins, and insulin are abundant in plasma under normal conditions. Thus, it is possible that these factors are also important in vivo (11,286,288,289) this concept was examined by taking platelet extract from humans and exposing it to rat aortic VSMCs. It caused proliferation of these cells, an effect that was more pronounced when the extract from diabetic vs normal subjects was used (290). Moreover, this increased proliferative effect by the platelet extract fiom diabetic patients was markedly reduced after treatment to normalize plasma glucose. This adds further support to the notion that either hyperosmolarity or some factor other than insulin contributes to the development of the atherosclerotic process. The AGE-receptor for AGE interaction in VSMC, in addition to growth factors induced by AGE, contributes to the stimulatory effects of diabetic sera on VSMC proliferation that can accelerate atherosclerosis (291). 

The receptor for AGE mediates uptake of glycated lipoprotein (RAGE) (354). 

Wang R, Kudo M, Yokoyama M, Asano G. Roles of advanced glycation endproducts (AGE) and receptor for AGE on vascular smooth muscle cell growth. J Nippon Med Sch 2001 68 472-481. 

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