Receptors dendrogram

P.J. Lewi, H. Moereels and D. Adriaensen, Combination of dendrograms with plots of latent variables. Application of G-protein coupled receptor sequences. Chemom. Intell. Lab. Syst., 16 (1992) 145-154. 

FIGURE 16-4 Evolutionary relationships between DNA sequences of GABAa receptors and glycine receptors. The dendrogram is based on literature data for human cDNAs, provided by Tim Hales and Ewen Kirkness, analyzed by Ziwei Chen, Kui Yang and Richard Olsen. 

The A3 adenosine receptor is different from the other three subtypes in many ways. Sequence identity of the human subtype to the human A1( A2A and A2B is only 54%, 46% and 43%, respectively, compared to 56% between A and A2A (Table 3.1). Also, the identity between species is remarkably low compared to other receptor subtypes (Table 3.2). The considerable species variation of the A3 adenosine receptor is also evident from a comparison of dendrograms. The high conservation of the... 

Fig. 3. Dendrogram showing the relationships among 5-HT receptors known from invertebrates.

Ffe. 5.14 Dendrogram of the protein sequences of chemosensory receptors and G-protein-coupled receptors, GPCRs. Although rhodopsin and serotonin receptors are clearly related between humans and Drosophila, the Drosophila olfactory receptors are unrelated to the olfactory receptors in vertebrates. (Reproduced from ref. 83 with permission of the authors and Nature.)... 

Figure 1. Dendrogram. The human 5-HTi [10], 5-HT,p [2], 5-HT p [6], 5-HTiut,[ll], rat 5-HT,b [12], 5-HT,c [13] and S-HTj [14] receptors were compared based on their sequence similarity. The relative lengths of the bars are inversely proportional to their sequence homology.

Fig. 8.9. Dendrogram showing the associations between neuroleptic compounds binding to 14 receptors (from Testa etal. 1983, with permission of Plenum Publishing Corporation).

---