Receptor signaling effect

Effect is linked to receptor signal. Thus, complex physiological patterns may be preserved. 

Thus, the non-zero , term reduces the effect of a on the pA2 estimate. It can be seen that when receptor signaling is blocked by the allosteric modulator ( = 0), Equation 7.34 reduces to Equation 7.32. 

Dopamine receptor signaling through the PKA pathway mediates many effects of psychomotor stimulants 918... 

Chronic opiate treatment results in complex adaptations in opioid receptor signaling. Much has been learned from studies on mechanisms of tolerance to the analgesic effects of opiates. This is a major clinical problem, as it means that ever-escalating doses are required for the treatment of chronic pain. The classic view was that tolerance reflects a decrease in functional opioid receptors via desensitization and internalization. Desensitization occurs when receptors are uncoupled from G proteins as a result of phosphorylation by G-protein-coupled receptor... 

Francesconi, A. and Duvoisin, R. (2000) Opposing effects of protein kinase C and protein kinase A on metabotropic glutamate receptor signaling selective desensitization of the inositol trisphosphate/Ca2+ pathway by phosphorylation of the receptor-G protein-coupling domain. Proc. Natl. Acad. Sci. USA 97,6185-6190. 

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