Receptor-Dependent Control of Arachidonate Mobilization

I have briefly described the structural, catalytic and pharmacological properties of various enzymes implicated in arachidonic acid 

Group 1 PLA2 Oleoyl oxyethylphosphorylcholine 6 ilVI Cell impermeable, reversible  

Group II PLA2 p-Bromo-phenacyl-bromide 43 nM Cell permeable, irreversible  

Group IV PLA2 [CPLA2I arachidonoyltrifluoromethylketone NA Selective for Group IV PLA2, cell permeable  

We have seen that a series of first messenger signaling molecules produce arachidonate mobilization by activating membrane receptors. Too many such effects have been described over the past 20 years to allow me to compile a review of this subject area that is both exhaustive and useful. I will rather illustrate with some examples what I consider to be the three major modalities of receptor-mediated control of arachidonate mobilization stimulation, inhibition and facilitation. Where possible, I will also indicate the specific transmembrane signaling pathway and enzyme route affected. 

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