Recent Progress in Calophyllum Coumarins as Potent Anti-HIV Agents

RECENT PROGRESS IN CALOPHYLLUM COUMARINS AS POTENT ANTI-HIV AGENTS 

Department of Medicinal Chemistry, Institute of Materia Medico, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing, Chirui 

Medicinal Chemistry of Bioactive Natural Products Edited by Xiao-Tian Liang and Wei-Shuo Fang Copyright 2006 John Wiley Sons, Inc. 

Numerous dipyranocoumarins have been isolated from different species of Calophyllum. According to their chemical skeleton, they have three heterocycle rings, ring B, C, and D, constructed from a phloroglucinol core A. These compounds fall into three basic structural types (1) tetracycle dipyranocoumarins in which the D rings have a gem-dimethyl group, such as (-l-)-calanolide A (1), (-l-)-calanolide B 

OCH3 R2=H (+)-12-methoxy calanolide OAc R2=H (+)-12-acetoxy calanolide A OCH3 Ri=H (+)-12-methoxy calanolide B 10 R=CH3 R2=0CH3 Ri=H (+)-12-methoxy cordatolide B  

---