Recent Advances in the Treatment of Insomnia

Albert Palomer, Marta Princep and Antonio Guglietta 

Insomnia is defined as a condition of unsatisfactory quantity and/or quality of sleep, which persists for a considerable period of time, including difficulty in falling asleep, difficulty in staying asleep, or early final wakening [1], Insomnia is the most 

Ferrer International S.A., Juan de Sada 32, 08028 Barcelona, Spain 

Annual Reports in Medicinal Chemistry, Volume 42 ISSN 0065-7743, DOI 10.1016/S0065-7743(07)42005-X 

Insomnia is associated with severe daytime dysfunction and low performance, related to traffic accidents and work absenteeism [7], with increasing medical burden, attributable to both direct medical and indirect costs [8]. 

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