Real proton transfer reaction mass

Steeghs M, Bais HP, de Gouw J, Goldan P, Kuster W, Northway M, Fall R, Vivanco JM (2004) Proton-transfer-reaction mass spectrometry as a new tool for real time analysis of root-secreted volatile organic compounds in arabidopsis. Plant Physiol 135 47-58... 

A proton transfer reaction-mass spectrometer (PTR-MS) system has been developed which allows on-line measurement of VOCs with concentrations as low as a few pptv (parts per trillion by volume) (Hansel et al., 1998). The acute measurement sensitivity to VOCs and real-time characteristics make it a very powerful tool in both indoor and outdoor environmental research. 

However, the desire to reduce or even eliminate the required sample preparation has led to the development of newer techniques, such as proton-transfer-reaction mass spectrometry (PTR-MS) and selected ion flow tube mass spectrometry coupled with ion mobility spectrometry (MS-SIFT IMS). These techniques allow real-time measurements within a single second. This enables analysis of gas composition during technological processes, monitoring of indoor air, and investigation of VOCs emitted by living organisms. 

L0kke, M. M., Edelenbos, M Larsen, E., Feilberg, A. (2012) Investigation by real time proton transfer reaction-mass spectrometry (PTR-MS) of volatiles emitted from freshly cut onions Allium cepa L.). Sensors 12, 16060. 

Beauchamp, J., Kirsch, E, Buettner, A. (2010) Real-time breath gas analysis for pharmacokinetics monitoring exhaled breath by on-line proton-transfer-reaction mass spectrometry after ingestion of eucalyptol-containing capsules. J. Breath Res. 4, 026006. 

Blake, R.S., Whyte, C, Hughes, C.O., Ellis, A.M., Monks, P.S. (2004) Demonstration of proton-transfer reaction time-of-flight mass spectrometry for real-time analysis of trace volatile organic compounds. Analytical Chemistry, 76,3841-3845. 

Trefe P, Schmidt M, Oertel P, et al. Continuous real time breath gas monitoring in the clinical environment by proton-transfer-reaction-time-of-flight-mass spectrometry. Anal Chem. 2013 2013 10321-9. 

Wieland, F, Gloess, A. N Keller, M. et al. (2012) Online monitoring of coffee roasting by proton transfer reaction time-of-fiight mass spectrometry (PTR-ToF-MS) towards a real-time process control for a consistent roast profile. Anal. Bioanal. Chem. 402, 2531. 

Mayhew, C. A., Sulzer, R, Petersson, F. et al. (2010) Applications of proton transfer reaction time-of-flight mass spectrometry for the sensitive and rapid real-time detection of solid high explosives. Int. J. Mass Spectrom. 289, 58. 

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