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Reagents alkenylation

Moreover, functionalized arylcopper reagents have been reported as appropriate nucleophiles with alkenyl and dienyl sulfonates (Table 5.3, entries 14—18) [18]. Although aryl sulfonates showed little reactivity towards arylcopper reagents, alkenyl sulfonates proved to be much more reactive under the described reaction conditions. [Pg.151]

Alkynyl anions are more stable = 22) than the more saturated alkyl or alkenyl anions (p/Tj = 40-45). They may be obtained directly from terminal acetylenes by treatment with strong base, e.g. sodium amide (pA, of NH 35). Frequently magnesium acetylides are made in proton-metal exchange reactions with more reactive Grignard reagents. Copper and mercury acetylides are formed directly from the corresponding metal acetates and acetylenes under neutral conditions (G.E. Coates, 1977 R.P. Houghton, 1979). [Pg.5]

Regiocontrolled q- or / -alkenylation and arylation of cyclic enones are possible without protection of the ketone by applying the coupling reaction of the Q- or /3-halo enones 607 and 608 with aryl and alkenylzinc reagents[468,469]. [Pg.214]

The alkenylzirconium 685, prepared by hydrozirconation of a terminal alkyne with hydrozirconocene chloride, reacts with alkenyl halide to afford the conjugated diene 686(545]. The Zr reagent can be used even in the presence of the carbonyl group in 687, which is sensitive to Al and Mg reagents. [Pg.228]

The dienone 858 is synthesized by coupling of the alkenyl copper reagent 856 with crotyl chloride (857) in the presence or absence of ZnCl2[731], Tetrabutyllead (859) reacts with benzoyl chloride to afford butyl phenyl ketone[732]. [Pg.255]

Ketones can be prepared by trapping (transmetallation) the acyl palladium intermediate 402 with organometallic reagents. The allylic chloride 400 is car-bonylated to give the mixed diallylic ketone 403 in the presence of allyltri-butylstannane (401) in moderate yields[256]. Alkenyl- and arylstannanes are also used for ketone synthesis from allylic chlorides[257,258]. Total syntheses of dendrolasin (404)f258] and manoalide[259] have been carried out employing this reaction. Similarly, formation of the ketone 406 takes place with the alkylzinc reagent 405[260],... [Pg.343]

Alkynes react with many of the same electrophilic reagents that add to the carbon-carbon double bond of alkenes Hydrogen halides for example add to alkynes to form alkenyl halides... [Pg.377]

The double bond m the alkenyl side chain undergoes addition reactions that are typical of alkenes when treated with electrophilic reagents... [Pg.447]

Organolithium reagents (Section 14 3) Lithi um metal reacts with organic halides to pro duce organolithium compounds The organic halide may be alkyl alkenyl or aryl Iodides react most and fluorides least readily bro mides are used most often Suitable solvents include hexane diethyl ether and tetrahy drofuran... [Pg.615]

Mixed-Metal Systems. Mixed-metal systems, where a zirconium alkyl is formed and the alkyl group transferred to another metal, are a new apphcation of the hydrozirconation reaction. These systems offer the advantages of the easy formation of the Zr—alkyl as well as the versatiUty of alkyl—metal reagents. For example, Cp2ZrRCl (R = alkyl or alkenyl) reacts with AICI3 to give an Al—alkyl species which may then be acylated with... [Pg.440]

The copper species formed depends on the solvent, and three different species were detected by F NMR, although the structure of each species was not elucidated [245 This copper reagent undergoes a variety of coupling reactions with aryl, alkenyl, allyl, and acetylenic halides [244, 245 (equation 162)... [Pg.709]


See other pages where Reagents alkenylation is mentioned: [Pg.391]    [Pg.45]    [Pg.299]    [Pg.391]    [Pg.45]    [Pg.299]    [Pg.46]    [Pg.276]    [Pg.185]    [Pg.209]    [Pg.210]    [Pg.212]    [Pg.215]    [Pg.215]    [Pg.216]    [Pg.218]    [Pg.224]    [Pg.228]    [Pg.229]    [Pg.238]    [Pg.242]    [Pg.249]    [Pg.254]    [Pg.345]    [Pg.348]    [Pg.349]    [Pg.314]    [Pg.320]    [Pg.361]    [Pg.548]    [Pg.36]    [Pg.45]    [Pg.433]    [Pg.592]    [Pg.945]    [Pg.45]   
See also in sourсe #XX -- [ Pg.426 ]




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Addition of Aryl-, Alkenyl- and Alkynylzinc Reagents to Aldehydes

Alkenyl 1.1-dimetallic reagent

Alkenyl chlorides with Grignard reagents

Alkenyl copper reagents

Alkenyl halides with Grignard reagents

Alkenyl iodides with Grignard reagents

Alkenyl lithium reagents

Alkenyl organocopper reagent

Alkenyl reagents, reactions

Alkenyl-Grignard reagent

Alkenylating reagents

Alkenylating reagents

Grignard reagents aryl-alkenyl reactions

Grignard reagents, reactions with alkenyl halides

Halides, alkenyl Grignard reagents

Organozinc reagents coupling reactions with alkenyl halides

Organozinc reagents with alkenyl halides

Reformatsky reagents with alkenyl halides

Stereochemical Integrity of Alkenyl Grignard Reagents

Substituted alkenyl Grignard reagents

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