Reactor 9 CPC Table-top Reactors

SEQUOS is an automated synthesis tool for drug discovery and process development it is an automated synthesis system which maintains precise control of reaction time, temperature and reactant concentration ratios, which allows syntheses to be conducted on a continuous basis from 50 mg up to the gram scale. By modification of the SEQUOS system it is also possible to produce quickly 100 g or kilogram quantities of target compounds utilizing the same instrument and reaction conditions. This eliminates the time and effort currently required for scale-up [37]. 

A new concept for combinatorial experimentation has been completed. Whilst it aims at the synthesis of focused compound libraries and at selecting the right reagent choices to conduct synthesis, it organizes around the same scaleable process used throughout the chemical synthesis process. Within this concept, variations of 

In one example sequence the technology has been used to synthesize a variety of amides from amines and acid anhydrides. It is currently also being used to optimize reactions through the variations of auxiliaries and solvents and might become an interesting and more direct alternative to solid-phase synthesis. 

Selected examples of a better chemistry performed in CPC table-top reactors 

Comparison of effort between conventional and micro reactor synthesis 

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