Buss loop reactor

Baier, F.O. Mass Transfer Characterization of a Novel Gas-Liquid Contractor. The Advanced Bus Loop Reactor Ph.D. thesis, Swiss Federation Institute-ETH Zurich, Switzerland, 2002. 

Fig. 29. Origin of systematic errors in spite of potentially error-free analysis. On-line sampling setups (top) and time trajectories of limiting substrate concentration during sample preparation in the two paradigmatic setups depending on the actual culture density (bottom). Either a filter in bypass loop is used for the preparation of cell-free supernatant (upper part in top insert) or an aliquot of the entire culture is removed using an automatic sampler valve and a sample bus for further inactivation and transport of the samples taken (lower part). Both methods require some finite time for sample transportation from the reactor outlet (at z = 0) to the location where separation of cells from supernatant or inactivation by adding appropriate inactivators (at z = L) takes place. During transport from z = 0 to z = L, the cells do not stop consuming substrate. A low substrate concentration in the reactor (namely s KS) and a maximal specific substrate consumption rate of 3 g g h 1 were assumed in the simulation example to reflect the situation of either a fed-batch or a continuous culture of an industrially relevant organism such as yeast. The actual culture density (in g 1 1) marks some trajectories in the mesh plot. Note that the time scale is in seconds...

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