Reactivity of Metal—Base Complexes toward Nucleophiles

REACTIVITY OF METAL-BASE COMPLEXES TOWARD NUCLEOPHILES 

The observations that cyanide and sulfur nucleophiles such as thiourea 

DDTC can inhibit platinum nephrotoxicity without affecting activity (Chapter 2.2). In this case, studies with model compounds showed that the bis(guanosine) complexes were not affected by DDTC (10 mM, 37 C) whereas a mono(guanosine) complex and a bis(adenosine) complex reacted readily with the DDTC ligand [137]. These results confirm observations from studies on DNA, where very little platinum is removed by DDTC at low binding ratios, and allow the prediction that DDTC should not reverse the toxic lesion on DNA, as observed [137]. It would be interesting to correlate the various effects of the nephroprotective sulfur nucleophiles (Chapter 2.2) and their effects on antitumour activity of cisplatin with the behavior toward model compounds (see also Chapter 3.7). 

---

Reactivity of metal—base complexes toward nucleophiles. 

---