Reactivity chiral aminophosphine ligands

This Mulheim chemistry has been highlighted by the discovery of the highly enantioselective hydrovinylation of styrene to produce chiral 2-phenyl-1-butene in 95.2% ee for a 10 kg-scale reaction (Scheme 60) (132). The Ni catalyst is very reactive and contains the unique chiral dimeric aminophosphine ligand derived from (R)-myrtenal and (S)-1-phenylethylamine. Computer simulations suggest that in this chiral Ni complex, the phenyl substituent of the chiral phenylethyl group acts as a windshield wiper across the catalytically active metal center. This... 

The enantiopure aminophosphines 56 were applied as building blocks for the construction of chiral ligands 58 and 59. The reactivity of the amino group should permit further functionalization which can result in novel structures that preserve... 

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