Reactive cellular sites

The cell membrane has receptor sites referred to as reactive cellular sites. Receptor sites on cell membranes are proteins, glycoproteins, proteolipids, or enzymes. 

The pharmaceutical response is realized when a dmg binds to a receptor on the cell membrane. These are referred to as reactive cellular sites. The activity of the dmg is determined by the dmg s ability to bind to a specific receptor. The better the fit, the more biologically active the dmg. Receptors are proteins, glycoproteins, proteolipids, or enzymes. Depending on the dmg, binding either initiates a physiological response by the cell or blocks a cell s physiological response. 

While PAL itself is recovered from the soluble fractions of cellular lysates via ultracentrifugation purifications, strong experimental evidence suggests it exists as part of a multienzyme complex associated with the endoplasmic reticulum (ER), forming a metabolic channel tunneling substrates directly from one enzymatic reactive site to another (Winkel 2004). The enzyme physically anchored to the ER is cinnamate... 

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