Reactions of 1,3-Dinucleophiles with Fluoro-containing 2- Dielectrophilic Building Blocks

Condensation Reactions of 1,3-Dinucleophiles with Fluoro-containing 1,2-Dielectrophilic Building Blocks 

Based on the same mechanistic concept, syntheses of perfluoro-benzo[ ]thiophenes and partially fluorinated indoles are described [67JCS(C)865, 67JCS(C)869, 67JCS(C)1189 68JCS(C)1225, 68TL4049]. 

Condensation Reactions of Fluoro-containing 1,3-Nucleo-philic I Electrophilic with 1,2-Nucleophilic I Electrophilic Building Blocks 

2-Amino-4,4,4-trifluoroacetylacetates represent three atomic building blocks having a nucleophilic and an electrophilic center in a 1,3-position. They readily react with (1,2 ne) compounds like CC, CO, CN double 

Perfluorothiophenol and acetylene react at 600°C to yield tetrafluoro-benzo[ )]thiophene (89JOU201). Similarly, 2,3,4,5,6-pentafluoro-l-thionaphtholate and dimethyl acetylene dicarboxylate give fluorinated naphtho[fe]thiophenes [89JFC(43)393]. 

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