Reactions of Chiral Molecules That Do Not Occur at the Stereogenic Center

Reactions of Chiral Molecules That Do Not Occur at the Stereogenic Center 

If a reaction of a chiral compound does not form or cleave any bonds to the stereogenic center, then the configuration of the product is the same as that of the reactant. Therefore, we can establish the absolute configuration of particular molecules using reference molecules of known absolute configuration. For example, 2-methyl-l-butanol is converted to l-bromo-2-methylbutane by HBr. The reaction does not occur at the stereogenic center. Therefore, the, 5-2-methyl-l-butanol yields S-1 -bromo-2-methylbutane. 

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