Reactions of benzyne with heterocyclic compounds

For a review of benzynes as dienophiles, see Hoffmann Dehydrobenzene and Cycloalkynes, Academic Press New York, 1967, pp. 200-239. For a review of the reactions of benzynes with heterocyclic compounds see Bryce Vernon Adv. Helerocycl. Chem. 1981,2, 183-229. 

Reactions of Benzyne with Heterocyclic Compounds M. R. Bryce and J. M. Vernon, Adv. Heterocycl. Chem., 1981, 28, 183-229. 

The variety and complexity of products described in these concluding examples drawn from the recent literature confirm the timeliness of this chapter on the reactions of benzyne with heterocyclic compounds, although we must still be far from the end of developments and discoveries in this field. 

Useful reviews on redox transformations of thiophen derivatives (179 references), on the stereochemistry of carbonyl derivatives of five-membered heterocycles (257 references), on synthetic approaches to dihydrothiophens (135 references), and on biosteric thiophens" have been published. Aspects of thiophen chemistry have been treated in reviews on the synthesis of heterocycles by thermal [2 + 2] cycloaddition reactions of acetylenes and on aspects and perspectives of organic heterocyclic chemistry. A review comparing the chemistry of thieno[2,3-h]- and thieno [3,2-i ]-thiophen with that of benzo[ft] thiophen and quinoline has been published. In Advances in Heterocyclic Chemistry, the development of benzo[6] thiophen from 1968 to 1980 and of selenophen from 1970 to 1980 was presented. Other aspects of thiophen chemistry are treated in chapters on Dewar Heterocycles," on Cyclizations under Vilsmeier Conditions, on Polyfluoroheteroaromatic Compounds, and on Reactions of Benzyne with Heterocyclic Compounds. " Several dissertations treating various aspects of thiophen chemistry have appeared. " ... 

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