Reactions of Amino-2,6-Naphthyridines

The hydrolysis of amino-1,5-naphthyridines has been covered in Section 4.1.1. Other reported reactions are illustrated by the following examples. 

3-Amino-l,5-naphthyridin-4 (1 //)-one (21) underwent diazotization to 3-diazo-nio-l,5-naphthyridin-4(1//)-one chloride (22) (substrate, Me2NCHO, 0°C, Me2CHCH2CH2ONO [, HCI/btOH [ 75%), which on irradiation gave 177-pyrrolo[3,2-b]pyridine-3-carboxylic acid hydrochloride (23) [substrate, AcOH, H20, 0°C, hv (arc lamp), h %].722 

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