Reaction with POCI

Apparently because of these side reactions, 2,4-dihydroxy-5,6,7-trimeth-ylpyrido[2,3-J]pyrimidine (46) on reaction with excess POCI, followed... 

A mixture of 61.7 g POCI, and 54.3 g N-methylformanilide was heated on the steam bath for 15 min which produced a deep red color. This was added to 54.3 g of 5-methoxy-1,2,3,4-tetrahydronaphthalene, and the mixture was heated on the steam bath for 2 h. The reaction mixture was quenched in 1.2 L H20 with very good stirring. The oils generated quickly turned to brown granular solids, which were... 

POCIS extracts and water samples were analyzed for the pharmaceuticals of interest as listed in Table 10.1. Standards and extracts were analyzed on a Quattro Micro triple quadrapole with a Waters 2695 high-pressnre liqnid chromatography (HPLC) and autosampler. Electrospray ionization in positive ion mode was used for detection of target compoimds by multiple reaction monitoring (MRM) with argon collision gas. A Thermo (Bellefonte, PA) Betabasic-18 column (250 x 2.1 mm, 5 p.m, 50°C) was used for separation at a flow rate of 0.2 ml/min with a gradient of methanol... 

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