Reaction temperature enhancement using microwave-assisted chemistry

In combinatorial chemistry, the reaction times and reaction temperatures required are frequently crucial factors. Microwave irradiation is used to enhance reaction rates [105]. Larhed et al. recently reported that microwave-assisted, palladium-catalyzed coupling of aryl and heteroaryl boronic acids with iodo- and bromo-substituted benzoic acids, anchored to Tenta-Gel S RAM, provides coupling products in excellent yields after a reaction time of just 3.8 minutes (45 W) [106]. The preparative results are summarized in Table 4. 

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