Reaction of HA with HO Radicals

Hydroxyl radicals (HO ) represent one of the most reactive species and may be generated in vitro by the Fe ion-induced decomposition of H O [59], by the light-induced scission of HjO or by H2O radiolysis [60]. Water hydrolysis is unequivocally the most specific method of HO radical generation and the radical yield can be easily altered by the applied energy dose [61]. 

HO radicals react in a diffusion-controlled manner (k=6xl0 1 mol s ) with virtually all compounds containing C-H groups under the abstraction of one hydrogen (H ) radical [62] leading to the generation of the corresponding alkyl 

Abstraction of one hydrogen radical from a (widely unspecific) 

C-H group under formation of the corresponding alkyl radical. 

The H abstraction occurs nearly randomly and there is only a very slight preference for selected positions. 

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