Reaction Initiated by Conjugate Addition

Domino Reactiom Concepts for Efficient Organic Synthe s, First Edition. Edited by Lute E. Tietee. 

13(6mol%) CuBr-SMe2 (5 mol%) MeMgBr (1.2 equiv), -BuOMe -75 C 

Feringa found that the Josiphos-type ligand 24 was the most effective one for addition of Grignard reagents to low-reactive coumarin 25. The resulting ester enolate 26 also underwent a subsequent aldol reaction with benzaldehyde. The 

The multimetal-mediated domino catalysis is one of the most powerful methodologies to give facile access to very complex chiral molecules. Feringa [17] developed domino 1,4-addition/allylation (Cu and Pd catalysis) followed by a ring-closing 

A facile asymmetric introduction of a nitrogen atom at the a-position of a carbonyl compound is of great importance in the synthesis of natural products and drugs. In 2007, Liu [23] presented the first enantioselective domino conjugate 

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Tandem reactions initiated by conjugate addition. A three-component condensation ... 

Enantioselective Cascade Reactions Initiated by Conjugate Addition... 

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