Reaction difluorobenzene derivatives

Less complex non-conjugated diene systems also lead to cubane-like derivatives as in the diene 175. Here the outcome of the reaction is dependent upon the excited state. Thus, direct irradiation brings about fragmentation with the formation of 1,4-difluorobenzene and excited-state naphthalene while triplet-sensitized irradiation follows a different path with the formation of the cage compound 17682. 

Yet another piperidine-based antipsychotic agent replaces the butyrophenone or diarylpropyl function found in earlier compounds by a benzopyrimidine group. The synthesis starts by the conversion of the carboxylic acid in piperidine (22-1) to its acid chloride. Reaction with 1,3-difluorobenzene (22-2) in the presence of aluminum chloride affords the acylated product (22-3). Reaction with hydroxylamine leads to the corresponding oxime (22-4). Treatment of that derivative with a base... 

Many applications of sodium and potassium organophosphides have been reported in the past year. The reaction of sodium diphenylphosphide with tosylates has been employed in the synthesis of steroidal phosphines. This reagent has also been used in the synthesis of a range of carbohydrate-derived phosphines, and in the synthesis of the phosphine (26), which can be linked to a silica support by treatment with acid. The reaction of sodium diphenylphosphide with o-difluorobenzene affords a convenient, one-pot synthesis of o-bis(diphenyl-phosphino)benzene. Sodium dimethylphosphide has been used to convert... 

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