RE Simulations using MC on a Continuous Potential

In contrast to the NRE model, the simplified model of RE based on the continuous potential has macrostates which, like real molecular systems, have microscopic internal structure and therefore is not guaranteed to have 

Behavior similar to that seen for the NRE model is also observed for the continuous potential the efficiency is nonmonotonic and exhibits a maximum 

This project has been supported in part by the National Institutes of Health Grants, GM-30580. 

Vendruscolo, E. Paci, Curr. Opin. Struct. Biol. 13, 82 (2003) 

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