Rational design strategy

Although until recently antibody humanization was based on arduous rational design strategies that require computer modeling and itera-... 

Initial design of the inhibitors was based on a rational design strategy using the renin substrate as a starting point. Some of the early studies indicated that the octapeptide of horse angiotensinogen (His-Pro-Phe-His-Leu-Leu-Val-Tyr), cleaved slowly by renin between the two leucine residues, was a weak competitive inhibitor of renin. This led to the modifications in the P, and P, positions (Leu-Leu) of this peptide. The early work indicated that the two leucine residues could be replaced by... 

Rational Design Strategies for Developing Synthetic Inhibitors of Helical Protein Interfaces... 

---