Rate enhancement from template stabilization

Autocatalysis in self-complementary systems is generally due to an efficient reaction within the complex T-A-B. If the reaction has no intermediate, or formation of an intermediate is rate limiting, rate enhancement is derived from the reduction in entropy caused by bringing together the reagents on a template. If breakdown of an intermediate is rate limiting (as in the case with our amide-forming replicators), rate enhancement is derived from template stabilization of an intermediate A-B such that product formation is favored over reversion to substrates. 

---