Ras-converting enzyme 1

Christiansen, J.R., Kolandaivelu, S., Bergo, M.O., and Ramamurthy, V. (2011). RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments. Proc Nad Acad Sci USA 108 8862-8866. 

The Ras Converting Enzyme (Rcelp) Orthologs, Enzymology, and Inhibitors... 

Cadinanos, J., et al. (2003). AtFACE-2, a prenylated-protem protease from Arabidopsis thaliana related to Ras converting enzymes. J Biol Chem 278 42091 2097. 

Hollander, L, Frommer, E., and Mahon, R. (2000). Human ras-converting enzyme (hRCEl) endoproteolytic activity on K-ras-derived peptides. Anal Biochem 286 129-137. 

Kyro, K., Manandhar, S.P., Daniel Muhen, D., Schmidt, W.K., and Distefano, M.D. (2010). Photoaffinity labeling of Ras converting enzyme 1 (Rcelp) using a benzophenone-contain-ing peptide substrate. Bioorg Med Chem 18(15) 5675-5684. 

GGTase-I [5], The specificities of FTase and GGTase are not absolute, and cross prenylation occurs which can be observed more readily for some substrates when one of the enzyme is inhibited. For example, K-Ras and N-Ras, which are the usual substrates for FTase, can be geranylgeranylated when the activity of FTase is suppressed [6]. The second and last steps of the modification process occur on the ER membrane and are catalyzed by Ras converting enzyme 1 (Reel) and isoprenylcysteine carboxylmethyl transferase (Icmt), both unique enzymes modify both farnesylated and geranylgeranylated proteins [1,7]. 

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