Rapid equilibrium trisubstrate

In Sections 12.2.1 and 12.2.2, we shall divide the rapid equilibrium trisubstrate mechanisms into the following major t)q)es ... 

Ordered and Random-Ordered Rapid Equilibrium Trisubstrate Systems... 

In this section, we shall reviewthe rate equations forthe majortypes of trisubstrate mechanisms, written in the absence of products (Cleland, 1963 Plowman, 1972 Fromm, 1975,1979). All trisubstrate mechanisms in the rapid equilibrium category are relatively rare and the steady-state mechanisms are more common. However, the derivation of rate equations for rapid equilibrium mechanisms, in the absence of products, is less demanding, as it requires only the rapid equilibrium assumptions and, therefore, the resulting rate equations are relatively simple. 

In all rapid equilibrium systems, aU Michaehs constants are always true dissociation constants of the complexes that dissociate. In aU trisubstrate mechanisms, aU inhibition constants are also always tme dissociation constants of the corresponding complexes. The temperature dependence of the equilibrium constants can be treated as described in Section 152.1 for a monosubstrate reaction. 

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