Ranitidine Nimodipine

Muck W, Wingender W, Seiberling M, Woelke E, Ramsch KD, Kuhlmann J. Influence of the H2-receptor antagonists cimetidine and ranitidine on the pharmacokinetics of nimodipine in healthy volunteers. Eur J Chn Pharmacol 1992 42(3) 325-8. 

After 7 days of antibiotic therapy with intravenous vancomycin, gentamicin, and ticarciUin + clavulanate for Pseudomonas aeruginosa and S. aureus sepsis, confluent erythematous-based vesicobuUae developed in a 65-year-old woman with subarachnoid hemorrhage secondary to a ruptured aneurysm (72). Other medications included ranitidine, glyceryl trinitrate, nimodipine, ferrous sulfate, and phenjrtoin. 

Cimetidine 1 g daily for 7 days ineieased the bioavailability of nimodipine 30 mg three times daily in 8 healthy subjects by 75%, but the haemodynamic effects were unchanged. Ranitidine did not interact. ... 

Ranitidine does not interact significantly with diltiazem, nimodipine, nisoldipine or nifedipine, and is possibly a non-interacting alternative for cimetidine with other calcium-channel blockers. Note that the nitrendipine AUC was increased by 50% and 89% by ranitidine, although this was not considered clinically relevant. 

---