Ranitidine HCl

Zantac 75 (ranitidine HCl) Warner Wellcome Stomach acid reducer... 

Guerrieri P, Salameh AK, Taylor LS (2007) Effect of small levels of impurities on the water vapor sorption behavior of ranitidine HCl. Pharm Res 24(1) 147-156. 

Floating microspheres Chitosan Ranitidine HCl Gastroretentive sustained drug release [105]... 

Hooda, A. Nanda, A. Jain, M. Kumar, V. Rathee, P. Optimization and evaluation of gastroretentive ranitidine HCl microspheres by using design expert software. Int. J. Biol. Macromol. 2012, 51 (5), 691-700. 

Singh et al. [123] prepared hydrogel from Sterculia gum modified with methacrylic acid and loaded with Ranitidine HCl. It was observed that the amount of drug released from per gram of the gel is higher in pH 2.2 as compared to pH 7.4 and distilled water. The monomer concentration, initiator concentration, amount of sterculia gum and concentration of crosslinker used diu ing the synthesis of hydrogels have affected the pore size and network density, which have been reflected in the swelling of the polymer matrix. 

Figure 4.12 Excipient percolation thresholds (expressed as %v/v HPMC + initial porosity)/ HPMC relative particle size versus the drug solubility in matrices containing acyclovir, theophiline, ranitidine HCl, acetaminophen, lobenzarit disodium and KCl.

Since there is a linear dependence of the percolation threshold of one component on its relative particle size, with the aim to correct the influence of the different relative particle size, the values of the excipient percolation threshold were divided by the excipient relative particle size [87]. The obtained results have been plotted against the solubility of the drugs studied in this work acetaminophen, theophylline and ranitidine-HCl. Moreover, data corresponding to hydrophilic matrices studied in previous works and containing different drugs—KCl, lobenzarit disodium and acyclovir—were also included, as it can be observed in Figure 4.12 [93, 94,96]. 

---