Ranitidine Aluminium hydroxide

Why are cimetidine and ranitidine better antacids than sodium hydrogencarbonate or magnesium or aluminium hydroxide ... 

Hebiig R, Boettcher M, Herman-Gnjidic Z, Pierce CH. Effects of magnesium/aluminium hydroxide-containing antacid, cimeti( ne or ranitidine on the pharmacokinetics of metrifonate and its metabolite DDVP. Clin Drug Invest (1999) 17, 67-77,... 

Roxithromycin did not alter the pharmacokinetics of carbamazepine (15) or interact with warfarin, ranitidine, or antacids containing hydroxides of aluminium and magnesium (1). 

Deppermam K-M, Lode H, Hoffken G, Tschink G, Kalz C, Koeppe P. Influence of ranitidine, pirenzepine, and aluminium m nesium hydroxide on die bioavailability of various antibacterials, includii amoxicillin, cep exin, dojq cycline, and amoxicillin-clavulanic acid. Antimi-crob Agents Chemother 9Z9)3> i, 1901-7. 

Reductions of up to 59% were found in another study. Yet another study showed that aluminium phosphate redueed the bioavailability of ranitidine by 30%. In contrast, another study found no signifieant ehanges in the pharmacokinetics of ranitidine given with an aluminium/magnesium hydroxide antacid (Maalcxx). 

Mylanta II (aluminium/magnesium hydroxide mixture) 30 mL reduced the ranitidine peak serum levels and AUC after a single 150-mg dose by about one-third in 6 healthy subjects. Mylanta Double Strength (aluminium/magnesium hydroxide with simeticone) reduced the absorption of ranitidine by 26%, which was not thought to be clinically significant. ... 

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