Randomized trial results treatment decision

Applying the results of randomized trials to treatment decisions for individual patients... 

It is the current attitude to question approved approaches to diagnosis and therapy and to ask for evidence-based medicine. If the treatment of special disorders is not evidence based, prospective, multicenter, randomized trials are proposed and further decisions strongly will depend on these findings. Meanwhile and for the years up to the first results of... 

Different types of evidence can be ranked in term of importance when decisions about clinical interventions are made (Figure 19.1).13,14 For example, the confidence from randomized controlled trials gives stronger evidence for treatment effects than open studies. Moreover, apparently conflicting results between studies may be compatible when a statistical meta-analysis of the data has been performed. This chapter will give a brief summary of evidence on the treatment effects of common dry skin disorders with urea-formulations. Furthermore, data on the influence of urea on the skin barrier function will be reviewed. 

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