Ramipril dosage

Maintenance dosage 2.5 to 20 mg/day as a single dose or in two equally divided doses. If BP is not controlled with ramipril alone, a diuretic can be added. 

In patients with severe CHF whose renal function may depend on the activity of the renin-angiotensin-aldosterone system, treatment with ACEIs may be associated with oliguria or progressive azotemia and, rarely, with acute renal failure or death. Impaired renal function decreases lisinopril elimination. The elimination half-life of quinaprilat increases as Ccr decreases. Dosage adjustment may be necessary for quinapril, benazepril, ramipril, and lisinopril. Impaired renal function decreases... 

Abdellatef, H.E. (2007) Spectrophotometric and spectrofluorimetric methods for the determination of ramipril in its pure and dosage form. Spectrochim Acta Part A, 66 (3), 701-706. 

Other ACE inhibitors. A placebo-controlled, randomised, crossover study in 16 hypertensive patients found that indometacin 50 mg twice daily reduced the blood pressure-lowering effects of cilazapril 2.5 mg daily. The reduction was greater when cilazapril was added to indometacin than when indometacin was added to cilazapril (approximately 60% versus 30% reduction in hypotensive effect measured 3 hours after the morning dose). The antihypertensive effects of perindopril 4 to 8 mg daily were also found to be reduced by about 30% by indometacin 50 mg twice daily in 10 hypertensive patients. A brief mention is made in a review that the pharmacodynamics of ramipril were unaffected by indometacin (dosage not stated) given to healthy subjects for 3 days. Indometacin 25 mg three times daily did not alter the hypotensive effects of trandolapril 2 mg daily in 17 hypertensive patients. ... 

Ramesh, B., Hari babu, K., Sarma, V.U.M., and Devi, PS. 2011. Development and validation of a HPTLC-ESI/MS method for the simultaneous determination of ramipril, hydrochlorothiazide and tehnisartan in tablet dosage form, J. Pharm. Res., 4 4541-4545. 

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