Ragweed allergen

TLR9 Covalently linked CpG B class ODN 1018ISS Tolamba (Amb a 1 ragweed allergen Allergic rhinitis (ragweed) P-II/m (DT)... 

Figure 1 Allergen-induced isolated early asthmatic response (EAR). FEV, (L) is on the vertical axis and time (hr) post-aUergen inhalation on the horizontal axis. Inhalation of ragweed allergen extract caused a 30% fall in FEV, maximal at 10 minutes and resolved by 2 hours (sohd tine) the response following inhaled diluent is shown in the dotted line.

Two weeks after a single systemic dose of omalizumab, given at a concentration in excess of semm IgE levels, five out of six monkeys had a reduction in the skin response to ragweed allergen, as demonstrated by an increase in the dose of ragweed required to elicit hive formation. After a second dose of omalizumab given 4 weeks later, all six monkeys evidenced reduced skin responsiveness. The reduced responsiveness persisted at week 10, 4 weeks after the second dose of omalizumab. These results occurred in parallel with a reduction in serum free IgE levels. 

Figure 6 The ECG and blood pressure in a ragweed-sensitized dog that was challenged with 0.15 U/mL of ragweed allergen, (a) without neural blockade, (b) with cooling the vagosympathetic trunks to 0°C, and (c) cooling the vagosympathetic trunks to 0°C and anesthetizing the cervicothoracic ganglia with lidocaine. The slower heart rate under these conditions is indicative of the removal of sympathetic tone.

Plantaginaceae, and Compositae. Ragweed (Ambrosia spp.) is the most important single allergenic plant on the North American continent and affects more of our citizens than does smog. Hay fever and similar allergies from weed pollen cause tremendous... 

Becker, C. G., Van Hamont, N., Wagner, M., Tobacco, cocoa, coffee and ragweed Crossreacting allergens that activate factor-XII-dependent pathways, Blood, 58, 861, 1981. (CA96 33194b)... 

King TP, Kochoumian L and Lichtenstein LM (1977) Preparation and immunochemical properties of methoxypolyethylene glycol-coupled and N-car-boxymethylated derivatives of ragweed pollen allergen, antigen E. Arch Biochem Biophysl78, 442-450. 

Robertson DG, Ketigan AT, Hargreave FE, Chalmers R, et al. 1974. Late asthmatic responses induced by ragweed pollen allergen. J All Clin Immunol. 54 244-254. 

Wopfner, N., Gadermaier, G., Egger, M. et al. 2005. The spectrum of allergens in ragweed and mugwort pollen. Int Arch Allergy Immunol 138 337-346. 

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